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Synthesis and Biological, Pharmacolgical Activites of Bioactive Benzothiazole Deravatives.

Ashok Kumar KV, and B Gopalakrishna

2-amino-6-fluoro-7-chloro (1,3) benzothiazoles are treated with aldehydes to get Schiff’s base (Azomethine) in presence of ethanol and HCl, then all the Schiff’s bases are separately refluxed with thioglycolic acid in presence of the solvent 1,4-dioxane and triturated with NaHCO3 solution results to give parent oxothiazolidine.The resulted azomethine (Schiff’s base) are treated with chloro acetyl chloride, triethylamine in presence of dioxane results gives the parent compounds of azetidinone. The identities of compounds were confirmed on the basis of their spectral (IR, 1HNMR and MASS) data further, they have been screened for their antifungal and anti-inflammatory activities.