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Significance of nutrigenomics in clinical diagnostics

K. Rudrama Devi

 Nutrigenomics is the application of genomics in the field of nutrition enabling associations between specific nutrients and genetic factors influence gene expression. This area provide information of diet related disease on a genome wide range and to understand the mechanisms underlying genetic predisposities. Such diet regulated genes likely to play a role in the onset, incidence progression and severety of chronic diseases. Modifying dietary intake can prevent monogenetic diseases. It also reveals why and how people respond differently to same nutrient. Global analysis techniques known as “omics” opened new avenules in nutrition. Advances in DNA sequencey micro assay, mass spectrometry and nuclear magnetic resonances have provided insights. Role of dietary components such as fruits, vegetables, plant extracts, micronutrients, macronutrients, carbohydrates, fibers, vitamins, protein in health maintance or in disease development. A compressive knowledge of genetic, epigenetic nutrition, non coding RNAs proteomic and metabolic and liptonic biomarkers and their significance in clinics will be presented. Biomarkers of exposure include biological biomarkers of exposure recommended for dietary food take. In clinics the biomarkers may help to formulate personalized dietary recommendation to achieve optimal health and wellness. Combining new information with personal nutritional biomarker profile and translating into to specific outcomes helps empowering citizens to have a healthiness optimal behaviour and life style adaptations.