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Ossifying Fibroma: Clinico-Pathologic and Immuno-Histochemical Investigation of 157 Cases in a Tertiary Referral Centre

Soyele OO, Braimah RO, Ibikunle AA, Taiwo AO, Gbotolorun MO and Aregbesolad SB

Background: Ossifying Fibroma (OF) belong to a group of lesions known as Fibroosseous lesions (FOL) whereby normal bone is replaced with fibrous tissue containing abnormal bone. OF is the most common benign fibroosseous lesions (FOLs) neoplasm of the oral and maxillofacial region. Methodology: This is a retrospective study of cases of histologically diagnosed maxillofacial OF in the department of Oral Biology and Oral Pathology, Lagos University Teaching Hospital, Idi-araba, Lagos, from 1970 to 2009. Haematoxylin and Eosin (H and E), Masson’s Trichrome Stain and AgNOR Stain were used to confirm the diagnosis of FD. Data was stored and analysed using IBM SPSS Statistics for windows version 20 (Armonk, NY: IBM Corp) and results presented in simple descriptive statistics and frequencies. Result: One hundred and fifty seven cases of OF, representing 52.0% of FOL were seen during the study period. OF was most commonly found in the age group of 20-29 years with a mean age of 30.14 ± 13.72 years. OF occur more frequently in females, 100 cases (63.69%) than males 57 cases (36.31%) at a female to male ratio of 1.75:1. OF occur more commonly in the mandible, 117 (74.52%) cases than maxilla 40 (25.48%) cases. High proportion of lamellar bone (31% and above) was demonstrated by Masson’s Trichrome Stain. Conclusion: This present study showed a female predilection and that OF was most commonly observed in the 3rd decade of life with mandibular bone predilection. In addition, it showed presence of lamella bone as predictor of OF using Masson’s trichrome (MT) stain.