抽象的

MMPs as Molecular Targets for Wound Healing by Musa sapientum: In-silico and In-vivo Evidences

Amit Singh, Abha Mishra, Sharad Verma, Manish K Gautam, and Raj Kumar Goel

The present work has been an attempt to study the wound healing by Musa sapientum (MS, banana). 50% ethanolic extract of Musa sapientum (MSE, 50-200 mg/kg) when administered as suspension showed dose-dependent increase in wound breaking strength in in vivo Incision wound rat model. MSE 100 mg/kg produced a significant increase in protein and collagen constituents like hydroxyproline, hexuronic acid and hexosamine in the connective tissue content of extracellular matrix when studied in Dead space wound model in rat. The role of leucocyanidin, an active constituent of MS was evaluated, in wound healing by in silico methods. In in-silico study leucocyanidin was taken for evaluation as MMPs inhibitor by molecular docking. Molecular docking showed that leucocyanidin was able to inhibit all selected MMPs, i.e. collagenase (-9.67 Kcal/mol), gelatinase (-8.67 Kcal/mol), elastase (-8.27 Kcal/mol) and stromelysin (-10.17 Kcal/mol).

免责声明: 此摘要通过人工智能工具翻译,尚未经过审核或验证

索引于

谷歌学术
打开 J 门
研究圣经
引用因子
宇宙IF
开放学术期刊索引 (OAJI)
学者指导
普布隆斯
国际创新期刊影响因子(IIJIF)
国际组织研究所 (I2OR)
宇宙
日内瓦医学教育与研究基金会
秘密搜索引擎实验室
欧洲酒吧

查看更多