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Comparative of Three Titrimetric Determinations of Cefazolin Sodium

Rechelo BS, Fernandes FHA, Kogawa AC, Pedroso TM and Salgado HRN

3 titration methods for quality evaluation of cefazolin sodium pharmaceutical product were developed and compared between them: acidimetric, iodometric and non-aqueous methods. The titrimetric methods consist of the measured volume of a solution, concentration of knowledge and need to completely react with a species to be quantified. A great advantage is measured without, in most analyzes, the analytical reference standard. Moreover, the smaller volume of solvent and high-end products. The developed methods meets the requirements of Brazilian Pharmacopeia and International Conference on Harmonisation, being fast, suitable, low cost, simple, accurate and can be used as an alternative for analysis of cefazolin sodium pharmaceutical product in laboratories and industry, contributing to improve the quality control of marketed drug.