抽象的

Comparative Anxiolytic Activity of Petroleum Extract of Valeriana jatamansi from Different Accessions in Mice

Anant V Bhandarkar, Shashidhara S, and Deepak M

Valeriana jatamansi Jones., (Family- valerianaceae) is a perennial herb or under shrub with a short, often strong smelling root stock. It is widely distributed in the temperate and cold regions of North West himalaya to Bhutan at altitude of 1200-3000m. The objective of the study was to test the anxiolytic effect of Valeriana jatamansi Jones., grown in India and Pakistan. Petroleum ether extract of both accessions were evaluated using ambulatory activity, elevated plus maze, spontaneous locomotor activity, motor coordination activity and sodium thiopental induced sleep in mice at dose of 75, 150 and 300 mg/ kg. Both the extract produced significant and dose dependent activity in the ambulatory and elevated plus maze test. The spontaneous locomotor activity count, measured using an actophotometer, was significantly decreased in animals at 120 min after administration of extract in both accessions. None of the extracts produced skeletal muscle relaxant effect assessed by rotarod test. Both extract produced a significant and dose dependent lengthening in the time of sodium thiopental sleep with the Pakistan valerian extract being more potent than Indian valerian. Thus we may conclude that, Pakistan valerian possess high anxiolytic potentials than Indian valerian.

索引于

谷歌学术
打开 J 门
研究圣经
引用因子
宇宙IF
开放学术期刊索引 (OAJI)
学者指导
普布隆斯
国际创新期刊影响因子(IIJIF)
国际组织研究所 (I2OR)
宇宙
日内瓦医学教育与研究基金会
秘密搜索引擎实验室
欧洲酒吧

查看更多