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Synthesis and Characterization of Pyrazolo[3,4-B] Quinoline ? a Finer Approach to the Drug Chemistry

K. Manjula Rani, S.P. Rajendran

Pyrazolo derivatives have been the basis of numerous drugs and dyes used in industries, hitherto of its possessing analgesic and antipyretic properties in addition to its base unit exhibiting dyeing characteristics. No doubt, owing to their synthetic utility in many products, interest in developing a new procedure becomes enviable. Quite a large number of medicinal plants in Indian subcontinent contain heterocyclic components in roots, stem and shoot system. Also a good number of the Pyrazolo derivatives are found in seeds, for example water melon seeds found to contain Pyrazolo in the concentration range of 250-410 μg/l on a specific variety. As for the bio synthetic activity is concerned, most plants have properties relating to anti-inflammatory, diagnostic acid, antibacterial, hypoglycemic, sedative-hypnotic etc. Herein, this paper deals with the synthesis and characterization of Pyrazolo derivative namely pyrazolidino [3, 4-b] quinoline by IR and NMR techniques. The data reveals the modified mode of synthesis from an intermediate stage up to the finalized product pertaining to the structure identified base as Pyrazolo quinoline.