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Pulmonary Tuberculosis in People with HIV: A Cross-sectional Study on the Characteristics Associated with the Negative Result of GeneXpert�?® MTB/RIF

Mariana Gaspar Botelho Funari de Faria1, Rubia Laine de Paula Andrade1*, Keila Diane Lima de Sousa1, Karina Fonseca de Sousa Leite1, Rafaele de Oliveira Bonfim1, Melisane Regina Lima Ferreira1, Paula Daniella de Abreu1, Valdes Roberto Bollela2, Ricardo Alexandre Arcêncio1, Carlos Eduardo Menezes de Rezende1,3, Gabriela Tavares Magnabosco4, Antônio Ruffino-Netto2, Tereza Cristina Scatena Villa1, Aline Aparecida Monroe1

This is a cross-sectional study which sought to analyze the effectiveness of the GeneXpert^® MTB/RIF test and the characteristics of pulmonary tuberculosis (TB) cases associated with the negative test result among people with HIV co-infection. The study was conducted in the state of São Paulo, Brazil, and the data were collected from the Information System in TB. The highest occurrence of negative result among the cases that performed the test was observed among: people aged 60 or older (PR 1.53; CI95% 1.22-1.93); females (PR 1.24; CI95% 1.08- 1.41); miliary TB (PR 1.99; CI95% 1.55-2.56); X-ray image suggestive of other pathologies (PR 1.83; CI95% 1.16-2.87); non-smokers (PR 1.20; CI95% 1.03-1.39); non-alcohol users (PR 1.21; CI95% 1.03-1.42); and non-users of illicit drugs (PR 1.33; CI95% 1.15-1.53). Thus, people with these characteristics deserve more attention when they present respiratory symptoms suggestive of TB in healthcare facilities.