Ch V Satya, C. Anuradha, D. Sri Rami Reddy
L-asparaginase is one of the known drugs in the treatment of cancer especially acute lymphoblatic leukemia. In this study, the production of high levels of L-asparaginase was obtained from Aspergillus wentiiin solid state fermentation using agro industrial wastes like coconut oil, palm oil, white and black sesame oil cakes. Palm oil cake showed maximum enzyme production with Aspergillus wentii when used as the substrate source in solid state fermentation (SSF). A 48 h fermentation time under aerobic conditions with moisture content of 89.51% and inoculum volume 30% V/W in SSF appeared optimal for enzyme production. The optimum temperature and pH for enzyme activity were 34oC and 5.8 respectively.
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