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Genetic Factors in Renal Failure and Diabetes Mellitus in the Black Population: A Systematic Review and Meta-Analysis

Danilo Ferreira de Sousa, Jackson Rodrigues Damasceno, Tahissa Frota Cavalcante, Márcio Flávio Moura de Araújo*, Thiago Moura de Araújo

Several risk factors for renal failure and diabetes mellitus have been identified, including genetic factors. The objective of this study was to analyse the influence of genetic risk factors on the development of renal failure and diabetes mellitus in the black population. This is a systematic review and meta-analysis prepared in accordance with the recommendations of the PRISMA protocol. The search was conducted during April 2018, using the following MeSH terms: "African Continental Ancestry Group", "Genetics", "and Diabetes mellitus “ and ” Renal insufficiency". After eligibility criteria were applied, a total of 31 studies were included in the review. According to the meta-analysis, genetic factors have a high effect size for the development of renal failure and diabetes mellitus with p<0.05. The results support the existence of susceptibility in the black population to the development of renal failure and diabetes mellitus.